|
KMID : 0379519990150030313
|
|
한국독성학회지
1999 Volume.15 No. 3 p.313 ~ p.321
|
|
|
Curcumin애 의해 유도된 egr-1 및 c-myc 유전자에 의한 발현 감소가 CpG oligodeoxynucleotide로 촉진된 미성숙 B 림프종 BKS-2의 성장 증가 억제
|
|
Han Seong-Su
Chung Seung-Tae
|
|
|
Abstract
|
|
|
|
To investigate the role of egr-1 and c-myc in immature murine B cell lymphoma BKS-2, we treated BKS-2 with curcumin and(or) CpG oligodeoxynucleotide(ODN). CpG ODN increased proliferation of BKS-2 cells up to 170% at 10 μM. The mRNA levels of egr-1 and c-myc were dramatically upregulated as early as 30 min following stimulation and decreased eventually with the 1 μM of CpG ODN. c-myc mRNA level was increased and peaked at 3 h. Curcumin treatment caused growth arrest of BKS-2 by dose-dependent manner and dramatically downregulated the expression of egr-1 and c-myc after 0.5 h until 6 h. Moreover, BKS-2 cells were growth arrested from CpG ODN mediated proliferation by the treatment with curcumin. 50 μM of curcumin treatment suppressed the expression of egr-1 and c-myc upregulated by CpG ODN. In summary. Curcumin caused the growth arrest of BKS-2 immature B-cell lymphoma and also inhibited the proliferation effect of CpG ODN to BKS-2 via downregulation of egr-1 and c-myc.
|
|
|
KEYWORD
|
|
|
Curcumin, CpG ODN, immature B cell lymphoma, egr-1, c-myc
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
 
|